Well now that I know you read comments.. maybe you’d consider helping change things for kids with cancer. I have a list of barriers and would love some feedback on ways to implement change. Children with osteosarcoma get the same 4-5 drugs and are sent home to die, over and over. The trials exclude most kids and it’s this fun game of it’s the fdas fault vs the fda saying they can’t require xyz (while children die). It is 2026. We don’t routinely test osteosarcoma tumors for anything until relapse. We do neoadjuvant chemo without strong evidence it improves outcomes. We do nothing until relapse, and then we only do what we know doesn’t work. In the name of safety of kids. I’m sure you’re seen a fair amount of people who die. Now imagine a child whose lungs are filled with painful bone tumors, having had limbs cut off and chest tumors from failed lung resections- dying of respiratory distress. And only having had MAP, ifos and Cabo. Kids need someone outspoken who people listen to- even if the media doesn’t like you- any attention will work. We can’t keep going on like this for the next 40 years
Yes and no Vinay. For one, with respect to Hepa filters, you can hardly write for "the whole of human history" when Hepa filters have not been in existence for that long. And by the way Hepa filters definitely take odor out of the air, and you would know that if you had dogs in the house!!
Second, absolutely the onus is on pharma to prove that their drug works. Likewise, when one RCTs things like ivermectin and HCQ with the aim of showing that they don't work, and hence designing the trial to ensure that they fail, the onus is on the experimenters to implement their RCT in the same way that these compounds are actually being used by real practitioners (i.e. with 24-48 hrs of the onset of symptoms in conjunction with a Z-pak, vitamin C, vitamin D, zinc, prednisone, etc....). Only then can the RCT claim that ivermectin and HCQ are useless. Until then the RCTs that have been conducted are totally useless.
Agreed. And there's nothing wrong with these "what-ifs?" In fact, there seem to be a lot of drugs where increasing the dose is what makes it work (vitamin C for example). But I agree, you have to admit "it doesn't work" until you figure out how to make it work. Maybe there's a better way to run trials with multiple levels and see if your outcomes are looking better one direction or just not changing at all.
Hepa filters schmeka filters. I do not understand why people are not more aware of the major caveat. Aerosols and particles drop to the floor with humidity, the more you swish the air around, you get more germs in the air, in the dryer air, where the float around more easily, and a dryer respiratory tract, making you MORE subject to catching sht.
Yes, it would be nice to run a RCT on all sorts of things including HEPA filter effects, but most of us cannot do that- it is impractical of course.. In the meantime we have to do the best we can. I have concluded that PM 2.5 levels that are elevated may have an association with any number of adverse health effects, so I run room HEPA filters in my home to reduce the PM 2.5 levels from toxic house dust and nearby roads. I can't prove that it helps me, or anybody over a lifespan, but it seems reasonable until we have an RCT. A quickie might be HEPA filters use in Mumbai and rate of asthma in kids who live there- a huge problem!
I’m really enjoying these articles, even though I just purchased a bunch of HEPA filters for my home AC last week. Lol
Agree with Marlon - getting rid of pollen and dust is really nice.
We use hepa filters because of allergies. They are fantastic for this!
I think it was covid specific.
Well now that I know you read comments.. maybe you’d consider helping change things for kids with cancer. I have a list of barriers and would love some feedback on ways to implement change. Children with osteosarcoma get the same 4-5 drugs and are sent home to die, over and over. The trials exclude most kids and it’s this fun game of it’s the fdas fault vs the fda saying they can’t require xyz (while children die). It is 2026. We don’t routinely test osteosarcoma tumors for anything until relapse. We do neoadjuvant chemo without strong evidence it improves outcomes. We do nothing until relapse, and then we only do what we know doesn’t work. In the name of safety of kids. I’m sure you’re seen a fair amount of people who die. Now imagine a child whose lungs are filled with painful bone tumors, having had limbs cut off and chest tumors from failed lung resections- dying of respiratory distress. And only having had MAP, ifos and Cabo. Kids need someone outspoken who people listen to- even if the media doesn’t like you- any attention will work. We can’t keep going on like this for the next 40 years
Consider looking up Pablove.org. They fund seed grants for out-of-the-box pediatric cancer research.
One of the recent seed grants was regarding metastatic osteosarcoma.
Thank you! Haven’t heard of it
If only I'd been 9 seconds faster I would have won a Gold Medal at the National Masters Time Trial Championships!
If only I had 10 million dollars…
Yes and no Vinay. For one, with respect to Hepa filters, you can hardly write for "the whole of human history" when Hepa filters have not been in existence for that long. And by the way Hepa filters definitely take odor out of the air, and you would know that if you had dogs in the house!!
Second, absolutely the onus is on pharma to prove that their drug works. Likewise, when one RCTs things like ivermectin and HCQ with the aim of showing that they don't work, and hence designing the trial to ensure that they fail, the onus is on the experimenters to implement their RCT in the same way that these compounds are actually being used by real practitioners (i.e. with 24-48 hrs of the onset of symptoms in conjunction with a Z-pak, vitamin C, vitamin D, zinc, prednisone, etc....). Only then can the RCT claim that ivermectin and HCQ are useless. Until then the RCTs that have been conducted are totally useless.
Add antimicrobial agents in hand soaps.
But in the spirit, if only I hadn't ruptured my ACL, I would have been in the FIFA world cup....
If only i was born with a 140 IQ ….🤣😭
some trials with humans are hard because people lie
some?
EVERYONE lies
Human science is the least scientific of all sciences. We need to be less empathetic and hysterical, and focus on animal and nature biology.
Modern humans live such anti-natural lives, we are doomed.
Agreed. And there's nothing wrong with these "what-ifs?" In fact, there seem to be a lot of drugs where increasing the dose is what makes it work (vitamin C for example). But I agree, you have to admit "it doesn't work" until you figure out how to make it work. Maybe there's a better way to run trials with multiple levels and see if your outcomes are looking better one direction or just not changing at all.
Are we, in the USA, only capable of advancing only one platform of therapeutic intervention at a point in time?
Hepa filters schmeka filters. I do not understand why people are not more aware of the major caveat. Aerosols and particles drop to the floor with humidity, the more you swish the air around, you get more germs in the air, in the dryer air, where the float around more easily, and a dryer respiratory tract, making you MORE subject to catching sht.
Stop with all the fans and "air cleaners"
They're all BAD
Yes, it would be nice to run a RCT on all sorts of things including HEPA filter effects, but most of us cannot do that- it is impractical of course.. In the meantime we have to do the best we can. I have concluded that PM 2.5 levels that are elevated may have an association with any number of adverse health effects, so I run room HEPA filters in my home to reduce the PM 2.5 levels from toxic house dust and nearby roads. I can't prove that it helps me, or anybody over a lifespan, but it seems reasonable until we have an RCT. A quickie might be HEPA filters use in Mumbai and rate of asthma in kids who live there- a huge problem!
Why do you want yet MORE studies, we have studies, they all say they're useless.
We need to stop wishing "stuff" made us healthier and focused on bettering our immune systems instead.