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Alex Eckelberry's avatar

Thank you for continuing to stay on top of this issue. There are so many whackjobs on both sides and yours is one of the few voices of reason.

The whole "following the Science" thing is just noise to me now. I have lost so much faith in our public health authorities, who are either a) running on panic, b) regurgitating Pfizer talking points, c) conflating politics with real needs and d) all of the above (the most common).

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KaiKai's avatar

Thank you once again for a summary of boostergeddon.

I read the editorial by Gruber and Krause. What I found most interesting was the concern they raised about "original antigenic sin" and boosters. It is something I have pondered since vaccination began based upon the dengue vaccine experience. Gruber and Krause wrote: "It’s also possible that repeatedly “training” the immune system to fight the original virus could reduce the effectiveness of a variant-specific booster. This phenomenon, called “original antigenic sin,” has been observed with influenza and human papillomavirus vaccines." Meaning the antigenic memory of today may interfere with the booster vaccine function in the future.

During this pandemic we have been trained, by pharma, to focus on neutralizing antibody levels, while ignoring the totality of our immune system including the cellular side. It is as though we have callosal disconnection syndrome were the right hand has no idea what the left is doing. Universal boosting epitomizes this.

Before the first VRBPAC meeting to discuss boosters I was contacted by a member of the VRB and asked my opinion on whether the Pfizer data showed boosters were safe and effective. My response was no. Small study, in-vitro data only, and no clinical data. I admire that member of the VRB for soliciting opinions from associates. We need more of that approach.

There has been far too much manipulation of data interpretation, inaccurate data reporting, narrative spin and politicization of the science of immunology, virology and public health. It is deeply disappointing. We have harmed STEM deeply. And yes much of it has occurred on the current president's watch.

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