Some claim that EUA needed to curb spread in high risk areas/ locations/ settings; Yet, that hypothesis has not been explicitly tested. All you know is titers are higher for some period of time. A different study design is needed to shed light on that Q.
Most physicians and much of the mainstream media are keen to approve of experimental treatments from multinational pharmaceutical companies, with governments jumping quickly to purchase the products. First it was vaccines and now various IV administered monoclonal antibodies and the potentially mutagenic https://www.inquirer.com/health/coronavirus/merck-covid-pill-fda-molnupiravir-dna-mutations-20211014.html viral RNA replication disruptor molnupiravir. Days after molnupiravir was announced, and before even the FDA or any other national regulatory agency gave any kind of approval for it, the Australian government ordered 300,000 treatment courses at about USD$700 each.
This global push for universal adoption (above some ever-lower age limit) of complex, invasive, months to administer, poorly researched vaccines, to the exclusion of vitamin D supplementation and other early treatments, is widely supported to the point of suppressing discussion and prescription of early treatments, including melatonin, ivermectin, quercetin and, most crucially, vitamin D (bolus D3 or calcifediol to boost levels in a few hours): https://c19early.com .
Even if the current vaccines are as safe and effective as their proponents insist, it is a mistake to portray current infections, harm and deaths as "the pandemic of the unvaccinated". This is the pandemic of the vitamin D deficient and of those who have not been able to receive early treatment. Vaccines run a poor third after vitamin D repletion (first) and multiple early treatments (joint second) in how best to suppress the pandemic.
Most physicians and immunologists have no idea that the immune system needs at least 50ng/ml 125nmol/L circulating 25-hydroxyvitamin D to mount strong innate and adaptive responses to bacterial pathogens. This is 2 to 10 times the levels most people have, without D3 supplementation or recent UV-B skin exposure. It is impossible to overstate the magnitude of this global disaster of billions of people, so under-supplied with the 25-hydroxyvitamin D they need, facing this virus with only slow to administer, expensive, narrow and rapidly declining vaccine-induced immunity with the next stop hospital treatment once hypoxia sets in. (Monoclonal antibodies are also being deployed on an outpatient basis, but it would be much better to get the patients' immune system working properly with bolus D3 or calcifediol, which _is_ 25-hydroxyvitamin D and so goes straight into circulation, without the need for hydroxylation in the liver over several days.)
The fundamental problem driving this lack of awareness about vitamin D and the immune system seems to be that most physicians simply cannot imagine that something so simple could be so important. This pattern of groupthink has been a catastrophic mistake, with the millions harmed and dead from COVID being the tip of an iceberg which includes millions of deaths from sepsis and other inflammatory disorders.
Most physician's are resistant to reading the research which clearly describes the mechanisms by which 25-hydroxyvitamin D enables individual immune cells to respond to their changing circumstances (autocrine and paracrine signaling) and to reduce inflammation, such as by enabling Th1 regulatory lymphocytes to transition from their pro-inflammatory startup program to their anti-inflammatory shutdown program, in response to a high level of a complement protein. McGregor et al. 2020 (link and summary: https://aminotheory.com/cv19/icu/#2020-McGregor) found that Th1 cells from the lungs of hospitalised COVID-19 patients can't transition, because their vitamin D based autocrine signaling system is not working, solely because they lack sufficient 25-hydroxyvitamin D.
Please read the most pertinent research articles, which are cited and summarised at "What every MD, immunologist, virologist and epidemiologist should know about vitamin D and the immune system": https://vitamindstopscovid.info/05-mds/
The crucial nutrient almost everyone is deficient in, which is required for good health and for suppressing COVID-19 severity, viral shedding and transmission, is sitting on the supermarket shelf. It has been ignored by most physicians for far too long. Since 2008 physicians and researchers (some are both) have been urging 40 to 60ng/ml to be recognised as the threshold of 25-hydroxyvitamin D repletion, rather than the 20ng/ml or 30ng/ml standards which are officially accepted: https://www.grassrootshealth.net/project/our-scientists/
We are in the midst of an unprecedented global health disaster, with experts, health professionals and lay people debating vaccines vs. lockdowns. Many people can't believe that so much suffering, harm and death could be caused by the lack of something so simple, safe, inexpensive (unprofitable) and easily available as vitamin D. They should read the research.
If the multinational pharmaceutical companies could patent something half as effective as vitamin D, they would sell it for hundreds or thousands of dollars per month of continual treatment. D3 is made in a handful of specialised factories (UV-B irradiation of 7-dehydrocholesterol, derived with some difficulty from wool fat) - none of them owned by big pharma companies. Most of this D3 goes to agricultural animals who live indoors (as do most humans). For 70kg 154lb bodyweight, 0.125mg (5000IU) D3 a day will, on average, raise circulating 25-hydroxyvitamin D levels safely over 50ng/ml after two or three months. This is a gram every 22 years, and pharma grade D3 sells for USD$2.50 a gram, in 1kg lots, ex-factory.
Some claim that EUA needed to curb spread in high risk areas/ locations/ settings; Yet, that hypothesis has not been explicitly tested. All you know is titers are higher for some period of time. A different study design is needed to shed light on that Q.
Most physicians and much of the mainstream media are keen to approve of experimental treatments from multinational pharmaceutical companies, with governments jumping quickly to purchase the products. First it was vaccines and now various IV administered monoclonal antibodies and the potentially mutagenic https://www.inquirer.com/health/coronavirus/merck-covid-pill-fda-molnupiravir-dna-mutations-20211014.html viral RNA replication disruptor molnupiravir. Days after molnupiravir was announced, and before even the FDA or any other national regulatory agency gave any kind of approval for it, the Australian government ordered 300,000 treatment courses at about USD$700 each.
This global push for universal adoption (above some ever-lower age limit) of complex, invasive, months to administer, poorly researched vaccines, to the exclusion of vitamin D supplementation and other early treatments, is widely supported to the point of suppressing discussion and prescription of early treatments, including melatonin, ivermectin, quercetin and, most crucially, vitamin D (bolus D3 or calcifediol to boost levels in a few hours): https://c19early.com .
Even if the current vaccines are as safe and effective as their proponents insist, it is a mistake to portray current infections, harm and deaths as "the pandemic of the unvaccinated". This is the pandemic of the vitamin D deficient and of those who have not been able to receive early treatment. Vaccines run a poor third after vitamin D repletion (first) and multiple early treatments (joint second) in how best to suppress the pandemic.
Most physicians and immunologists have no idea that the immune system needs at least 50ng/ml 125nmol/L circulating 25-hydroxyvitamin D to mount strong innate and adaptive responses to bacterial pathogens. This is 2 to 10 times the levels most people have, without D3 supplementation or recent UV-B skin exposure. It is impossible to overstate the magnitude of this global disaster of billions of people, so under-supplied with the 25-hydroxyvitamin D they need, facing this virus with only slow to administer, expensive, narrow and rapidly declining vaccine-induced immunity with the next stop hospital treatment once hypoxia sets in. (Monoclonal antibodies are also being deployed on an outpatient basis, but it would be much better to get the patients' immune system working properly with bolus D3 or calcifediol, which _is_ 25-hydroxyvitamin D and so goes straight into circulation, without the need for hydroxylation in the liver over several days.)
The fundamental problem driving this lack of awareness about vitamin D and the immune system seems to be that most physicians simply cannot imagine that something so simple could be so important. This pattern of groupthink has been a catastrophic mistake, with the millions harmed and dead from COVID being the tip of an iceberg which includes millions of deaths from sepsis and other inflammatory disorders.
Most physician's are resistant to reading the research which clearly describes the mechanisms by which 25-hydroxyvitamin D enables individual immune cells to respond to their changing circumstances (autocrine and paracrine signaling) and to reduce inflammation, such as by enabling Th1 regulatory lymphocytes to transition from their pro-inflammatory startup program to their anti-inflammatory shutdown program, in response to a high level of a complement protein. McGregor et al. 2020 (link and summary: https://aminotheory.com/cv19/icu/#2020-McGregor) found that Th1 cells from the lungs of hospitalised COVID-19 patients can't transition, because their vitamin D based autocrine signaling system is not working, solely because they lack sufficient 25-hydroxyvitamin D.
Please read the most pertinent research articles, which are cited and summarised at "What every MD, immunologist, virologist and epidemiologist should know about vitamin D and the immune system": https://vitamindstopscovid.info/05-mds/
The crucial nutrient almost everyone is deficient in, which is required for good health and for suppressing COVID-19 severity, viral shedding and transmission, is sitting on the supermarket shelf. It has been ignored by most physicians for far too long. Since 2008 physicians and researchers (some are both) have been urging 40 to 60ng/ml to be recognised as the threshold of 25-hydroxyvitamin D repletion, rather than the 20ng/ml or 30ng/ml standards which are officially accepted: https://www.grassrootshealth.net/project/our-scientists/
We are in the midst of an unprecedented global health disaster, with experts, health professionals and lay people debating vaccines vs. lockdowns. Many people can't believe that so much suffering, harm and death could be caused by the lack of something so simple, safe, inexpensive (unprofitable) and easily available as vitamin D. They should read the research.
If the multinational pharmaceutical companies could patent something half as effective as vitamin D, they would sell it for hundreds or thousands of dollars per month of continual treatment. D3 is made in a handful of specialised factories (UV-B irradiation of 7-dehydrocholesterol, derived with some difficulty from wool fat) - none of them owned by big pharma companies. Most of this D3 goes to agricultural animals who live indoors (as do most humans). For 70kg 154lb bodyweight, 0.125mg (5000IU) D3 a day will, on average, raise circulating 25-hydroxyvitamin D levels safely over 50ng/ml after two or three months. This is a gram every 22 years, and pharma grade D3 sells for USD$2.50 a gram, in 1kg lots, ex-factory.